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Segar notes, Many of these interactions are based on mechanistic data, animal data, and isolated case reports. This means that many of the potential interactions in the list above havent been confirmed in human studies

A recent systematic review and meta-analysis of 25 observational studies found proton-pump inhibitor use was associated with a small increased risk of vitamin B 12 deficiency

Acknowledgements We are thankful to the support of China Pharmaceutical University and all those who have assisted in improving the quality of this article

A survey of two dozen studies showed that B12 can be an effective treatment for peripheral neuropathy for both short-term pain relief and longer-term nerve regeneration